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MSSA
- Cloxacillin is first line
- Cephalexin/cefazolin
- Clindamycin (fading coverage for MSSA)
MRSA
- Vancomycin is first line (especially for hospital associated MRSA)
- Other options
- Ceftaroline (5th generation cephalosporin)
- Oral options for outpatient management can be used for community associated MRSA
- Options
- TMP-SMX (septra) but also available in IV
- Risk factors
- Prison, indigenous, MSM, contact sports
VRE
- Linezolid
- Daptomycin
- Tigecycline
Pseudomonas
- Piperacillin/tazobactam (Piptazo)
- Also has anaerobic coverage
- Ceftazidime (3rd generation cephalosporin)
- Cefepime (4th generation cephalosporin)
- Ceftobiprole (5th generation cephalosporin)
- Carbapenems (except ertapenem)
- Aminoglycosides
- Gentamicin, Amikacin, tobramycin, neomycin, streptomycin
- PO option
Anaerobic coverage
- Penicillin + beta-lactamase inhibitor
- Piperacillin/tazobactam (Piptazo)
- Amoxicillin/clavulanate
- Ampicillin/sulbactam
- Carbapenems
- Clindamycin
- Metronidazole
- Moxifloxacin (fluoroquinolones)
- Tigecycline